ABSTRACT
Objection: The psychological health of thyroid cancer patients cannot be ignored, however, few studies have been conducted on the psychological status and influencing factors of thyroid cancer patients before radioactive iodine (RAI) therapy. The aim of the study was to investigate the incidence and risk factors of anxiety and depression in thyroid cancer patients prior to RAI therapy. Methods: : Clinical data were collected among differentiated thyroid cancer patients (DTCs) preparing for RAI therapy. Anxiety and depression were measured before RAI therapy by using the Generalized Anxiety Disorder Questionnaire (GAD-7) and Patient Health Questionnaire (PHQ-9). We used chi-square test and logistic regression analysis to find independent risk factors for anxiety and depression. Results: : A total of 112 patients with thyroid cancer were included. Of these, 72.32 % (n=81) were female, with an mean age of 41.50 years. Anxiety and depression were reported by 46 (41.08%) and 38 (33.93%) patients, respectively. Based on chi-square test and univariate logistic regression analysis, being female and having ever-experienced RAI therapy were independent risk factors for anxiety and depression among DTCs prior to RAI therapy. On multivariate analysis, only being female was significant associated with anxiety and depression in these patients. Conclusions: : Incidence of anxiety and depression increased in DTCs prior to RAI therapy. Being female and ever-experienced RAI therapy significant influenced anxiety and depression. Based on these findings, anxiety and depression assessment should be an important part of pre-RAI therapy in DTCs, and appropriate psychological nursing intervention can be carried out for key patients.